Original classroom practice · grades 6–12

Biology vocabulary crossword vocabulary pack

Practice core terms from cells, genetics, biomolecules, energy processes, inheritance, and adaptation.

Teacher move: Have students connect each answer to a labeled cell, inheritance example, or biological process.

Name: ____________________Date: ____________________
#ClueLettersLevelCandidate and evidence
1Body-cell division that produces matching nuclei7intermediateCandidate: ____________________
Evidence: __________________________________
2Cell division that halves chromosome number for gametes7advancedCandidate: ____________________
Evidence: __________________________________
3Threadlike DNA package in a cell nucleus10intermediateCandidate: ____________________
Evidence: __________________________________
4DNA segment linked to a trait4introductoryCandidate: ____________________
Evidence: __________________________________
5Version of a hereditary DNA unit6intermediateCandidate: ____________________
Evidence: __________________________________
6An organism's allele combination8intermediateCandidate: ____________________
Evidence: __________________________________
7Observable expression of a trait9intermediateCandidate: ____________________
Evidence: __________________________________
8Cell structure where proteins are assembled8intermediateCandidate: ____________________
Evidence: __________________________________
9Plant organelle that captures light to make sugar11intermediateCandidate: ____________________
Evidence: __________________________________
10Organelle where much cellular ATP is produced13advancedCandidate: ____________________
Evidence: __________________________________
11Membrane-bound cell compartment holding DNA7introductoryCandidate: ____________________
Evidence: __________________________________
12Movement from higher concentration to lower concentration9intermediateCandidate: ____________________
Evidence: __________________________________
13Movement of materials across a cell membrane9introductoryCandidate: ____________________
Evidence: __________________________________
14Biological molecule that speeds a reaction6intermediateCandidate: ____________________
Evidence: __________________________________
15Macromolecule made from amino acids7introductoryCandidate: ____________________
Evidence: __________________________________
16Fat-like biomolecule that does not mix well with water5introductoryCandidate: ____________________
Evidence: __________________________________
17Biomolecule group that includes sugars and starches12intermediateCandidate: ____________________
Evidence: __________________________________
18Cell process that releases energy from food molecules11intermediateCandidate: ____________________
Evidence: __________________________________
19Energy process cells can use without oxygen12intermediateCandidate: ____________________
Evidence: __________________________________
20Inherited trait that helps survival or reproduction10introductoryCandidate: ____________________
Evidence: __________________________________

Reflection

Which clue detail gave you the strongest evidence, and what did it rule out?

Teacher key

  1. MITOSIS · 7 letters · noun · intermediate
    Body-cell division that produces matching nuclei

    Hint: This process supports growth and tissue repair.
    Why it fits: MITOSIS fits because ordinary body cells use this process to make cells with the same chromosome set.

  2. MEIOSIS · 7 letters · noun · advanced
    Cell division that halves chromosome number for gametes

    Hint: It helps offspring differ from their parents.
    Why it fits: MEIOSIS is correct because sperm and egg cells form through divisions that reduce and shuffle chromosomes.

  3. CHROMOSOME · 10 letters · noun · intermediate
    Threadlike DNA package in a cell nucleus

    Hint: Humans usually have 46 of these in body cells.
    Why it fits: CHROMOSOME fits because it is the organized structure that carries hereditary information inside many cells.

  4. GENE · 4 letters · noun · introductory
    DNA segment linked to a trait

    Hint: A short hereditary unit can influence a characteristic.
    Why it fits: GENE is correct because traits are influenced by DNA segments passed from parents to offspring.

  5. ALLELE · 6 letters · noun · intermediate
    Version of a hereditary DNA unit

    Hint: For a blood type trait, A and O are examples.
    Why it fits: ALLELE fits because organisms can carry different versions of a gene that affect how a trait appears.

  6. GENOTYPE · 8 letters · noun · intermediate
    An organism's allele combination

    Hint: Letters like Bb can represent it in a Punnett square.
    Why it fits: GENOTYPE is correct because it names the genetic makeup represented by allele symbols, not the visible trait itself.

  7. PHENOTYPE · 9 letters · noun · intermediate
    Observable expression of a trait

    Hint: Flower color or pea shape can be this visible result.
    Why it fits: PHENOTYPE fits because it names the visible or measurable form of a trait, such as height or color.

  8. RIBOSOME · 8 letters · noun · intermediate
    Cell structure where proteins are assembled

    Hint: It reads RNA instructions during translation.
    Why it fits: RIBOSOME is correct because this cellular machine translates RNA messages into chains of amino acids.

  9. CHLOROPLAST · 11 letters · noun · intermediate
    Plant organelle that captures light to make sugar

    Hint: It contains green pigment and is common in leaf cells.
    Why it fits: CHLOROPLAST fits because this organelle houses the reactions that convert light energy into chemical energy.

  10. MITOCHONDRION · 13 letters · noun · advanced
    Organelle where much cellular ATP is produced

    Hint: It is often nicknamed the cell's power site.
    Why it fits: MITOCHONDRION is correct because many eukaryotic cells rely on this organelle for large amounts of usable energy.

  11. NUCLEUS · 7 letters · noun · introductory
    Membrane-bound cell compartment holding DNA

    Hint: In many diagrams, it is drawn as the large central cell part.
    Why it fits: NUCLEUS fits because it houses chromosomes and helps regulate cell activities through genetic instructions.

  12. DIFFUSION · 9 letters · noun · intermediate
    Movement from higher concentration to lower concentration

    Hint: A drop of dye spreading through water shows the idea.
    Why it fits: DIFFUSION is correct because particles tend to spread out until their concentration becomes more even.

  13. TRANSPORT · 9 letters · noun · introductory
    Movement of materials across a cell membrane

    Hint: It may require energy when particles move against a gradient.
    Why it fits: TRANSPORT fits because cells use passive and energy-requiring mechanisms to move substances where they are needed.

  14. ENZYME · 6 letters · noun · intermediate
    Biological molecule that speeds a reaction

    Hint: It lowers activation energy and is not used up.
    Why it fits: ENZYME is correct because cells rely on these catalysts to make many reactions occur fast enough for life.

  15. PROTEIN · 7 letters · noun · introductory
    Macromolecule made from amino acids

    Hint: Enzymes and many cell structures are built from this material.
    Why it fits: PROTEIN fits because chains of amino acids form molecules that support structure, signaling, transport, and catalysis.

  16. LIPID · 5 letters · noun · introductory
    Fat-like biomolecule that does not mix well with water

    Hint: Cell membranes contain a double layer of this molecule type.
    Why it fits: LIPID is correct because these molecules store energy, form membranes, and resist mixing with water.

  17. CARBOHYDRATE · 12 letters · noun · intermediate
    Biomolecule group that includes sugars and starches

    Hint: Cells often use this molecule type for quick energy or structure.
    Why it fits: CARBOHYDRATE fits because glucose, starch, and cellulose all belong to this energy and structure-related molecule group.

  18. RESPIRATION · 11 letters · noun · intermediate
    Cell process that releases energy from food molecules

    Hint: Its aerobic form uses oxygen and produces ATP.
    Why it fits: RESPIRATION is correct because cells convert chemical energy in molecules such as glucose into ATP through this process.

  19. FERMENTATION · 12 letters · noun · intermediate
    Energy process cells can use without oxygen

    Hint: Yeast use it when making bread rise.
    Why it fits: FERMENTATION fits because it regenerates molecules needed for glycolysis when oxygen is unavailable.

  20. ADAPTATION · 10 letters · noun · introductory
    Inherited trait that helps survival or reproduction

    Hint: Thick fur in a cold habitat can be one example.
    Why it fits: ADAPTATION is correct because natural selection can favor traits that help organisms succeed in particular conditions.

Accept a different answer only when it matches the clue, length, grammar, and any supplied crossings. Use the reviewed answer when teaching the intended vocabulary target.

All clues in this pack are original classroom material from Crossword Clue Tutor and may be printed for classroom use.